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Personalized Drug Screening for Functional Tumor Profiling Victoria El-Khoury

Personalized Drug Screening for Functional Tumor Profiling By Victoria El-Khoury

Personalized Drug Screening for Functional Tumor Profiling by Victoria El-Khoury


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Summary

This Element discusses personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.

Personalized Drug Screening for Functional Tumor Profiling Summary

Personalized Drug Screening for Functional Tumor Profiling by Victoria El-Khoury

Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.

Table of Contents

1. Rationale for functional profiling in oncology; 2. Tumor models in drug screening; 3. Cell-based screening platforms for personalized medicine; 4. Drug repurposing in personalized oncomedicine; 5. Clinical applications of drug screening in oncology; 6. Conclusions and perspectives; References.

Additional information

NPB9781009016933
9781009016933
1009016938
Personalized Drug Screening for Functional Tumor Profiling by Victoria El-Khoury
New
Paperback
Cambridge University Press
2022-07-07
75
N/A
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