Preface
Acknowledgments
Part I. Basics of Genetics
Chapter 1. Individual Differences: The Role of Genetics in Exercise Science and Health
-Hidden Aspect of Average Values
-Why Do We See Variation in a Physical Trait?
-Summary
-Learning Aids
Chapter 2. DNA, RNA, and Protein
-Basic Cell Biology
-DNA
-Our Genetic Material as Chromosomes
-Special Focus: The Human Genome Project
-RNA
-Amino Acids and Proteins
-Structure of Genes
-Summary
-Learning Aids
Chapter 3. Transcription, Translation, and the Genetic Code
-Moving From DNA to RNA: Transcription
-Posttranscriptional Modifications of RNA
-Moving From RNA to Protein: Translation
-Posttranslational Modifications of Proteins
-Genetic Code
-Summary
-Learning Aids
Chapter 4. Moving Genetic Material to the Next Generation
-Basic Reproduction
-Sex Cell Production and Meiosis
-Special Focus: Mitosis Versus Meiosis
-Chromosomal Recombination
-Mendelian Inheritance Patterns
-Summary
-Learning Aids
Chapter 5. Heritability and the Basics of Genetic Variation
-Familial Resemblance: Genes and Environment
-Heritability as a Measure of Genetic Contribution
-Special Focus: Twin and Family Studies
-Genetic Variation
-Types of Genetic Variation
-Special Focus: Labeling Polymorphisms
-How Genetic Variation Can Influence Physical Traits
-How Do Polymorphisms Arise? Genetic Variation and Evolution
-Summary
-Learning Aids
Chapter 6. Genetic Variation and Disease
-Mendelian Disease Genetics
-Special Focus: Muscular Dystrophy
-Complex Disease
-Special Focus: Obesity as a Complex Trait
-Gene x Environment Interactions
-Gene x Gene Interactions
-Summary
-Learning Aids
Chapter 7. Linkage Disequilibrium, Haplotype, and Environmental Interaction
-Recombination Revisited
-Linkage Disequilibrium
-Linkage Analysis in Families
-Haplotype: Combinations of Neighboring Alleles
-Special Focus: The International HapMap Project
-Diplotype: Combinations of Haplotypes
-Gene x Environment Interaction Revisited
-An Introduction to Epigenetics
-Summary
-Learning Aids
Part II. Research Design and Methods
Chapter 8. Getting Started: Basic Skills for Genetics Research
-Is Genetic Variation Important for My Trait of Interest?
-Using PubMed
-Interpreting Existing Literature
-Identifying and Selecting Candidate Genes and Polymorphisms
-Using Genome Databases
-Summary
-Learning Aids
Chapter 9. Issues in Study Design and Analysis
-How Genetics Necessarily Alters Study Design
-Typical Study Designs
-Subject Recruitment
-Geographical Ancestry
-Special Focus: Race in Genetics
-Prospective Versus Retrospective
-Statistical Approaches
-Interpretation of Results: Association versus Cause and Effect
-Summary
-Learning Aids
Chapter 10. Basic Laboratory Methods in Genetics
-DNA from Blood or Cheek Cells
-Polymerase Chain Reaction (PCR)
-Genotyping with Restriction Enzymes
-Genotyping with Fluorescent Tags
-Special Focus: DNA Microarrays
-DNA Sequencing
-Summary
-Learning Aids
Part III. Current Findings and Extensions of Genetics Research
Chapter 11. Current Research Findings in the Genetics of Exercise Science and Health
-Overview of Current Findings
-Special Focus: The Human Gene Map for Performance and Health-Related Fitness Phenotypes
-ACTN3 and Muscular Performance
-ApoE and Cognitive Impairment
-ACE and Sport Performance
-Myostatin and Muscle Mass
-Summary
-Learning Aids
Chapter 12. Personalized Medicine
-Genetics and Complex Disease Revisited
-Promise and Limitations of Personalized Medicine
-Special Focus: Pharmacogenomics
-Genetics in Nutrition and Exercise Prescription
-Genetics in Disease Prevention
-Summary
-Learning Aids
Chapter 13. Ethical Challenges in Genetics and Society
-Ethical, Legal, and Social Implications of Genomics Gene Therapy for Disease Treatment
-Special Focus: Stem Cells
-Genetics in Sport: Genetic Testing and Gene Doping for Performance
-Summary
-Learning Aids
Appendix A: Answers to Review Questions
Appendix B: Evolution and Hardy-Weinberg Equilibrium
Glossary
Bibliography
Index
About the Author