This is a third edition of the best known introduction to EBM. This is a pocket-sized introduction which tells the reader how to integrate the best available evidence with his or her own clinical expertise, written by world-renowned authorities. Following the retirement of David Sackett from the EBM field and the author team of the book, his colleagues have revised the book throughout and, in answer to common criticisms have focussed on how EBM can be practiced in real time in a variety of clinical settings.