Cross Academy is attended by two groups of students: the Day Class and the Night Class. At twilight, when the students of the Day Class return to their dorm, they cross paths with the Night Class on their way to school. Yuki Cross and Zero Kiryu are the Guardians of the school, protecting the Day Class from the Academy's dark secret: the Night Class is full of vampires!

Kaname has returned to Cross Academy to kill Sara Shirabuki. Zero has joined forces with Sara, leaving Yuki in the middle of the conflict. Even if Kaname's ultimate goal is to kill all purebloods, is Yuki ready to fight him?