Preface. 1. Mouse Natural Resistance Associated Macrophage Protein 1 (Nramp1): A Key Player in Host Innate Immunity Against Infections; Nada Jabado, Steven Lam-Yuk-Tseung, John R. Forbes and Philippe Gros.
Why Mouse Models? Nramp1: A Mouse Host Resistance Locus.- Pathogens Under Nramp1 Control.- Nramp1 Gene and Protein Expression in Macrophages.- The Nramp Gene Family.- Divalent Cation Transport by Nramp Proteins.- Nramp1 Dependent Divalent Cations Transport
at the Phagosomal Membrane.- Structure/Function Studies by Site Directed Mutagenesis.- Divalent Cation Transport and Resistance to Infections.- Nramp1 and Phagosomal Maturation .
2. Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals; Judith Caron, Danielle Malo, Christopher Schutta, Joe W. Templeton and L. Garry Adams.
Comparative Genomics.- Nramp1.- Chicken Genomics, Salmonella Infection and NRAMP1.- Bovine Genomics, Brucella abortus Infection and NRAMP1.
3. The NRAMP Genes and Human Susceptibility to Common Diseases; Audrey Poon and Erwin Schurr.
NRAMP1 Gene Location and Structure.- NRAMP1 Polymorphisms.- NRAMP1 Function.- NRAMP1 and Infectious Diseases Susceptibility.- NRAMP1 and Autoimmune Diseases Susceptibility.- NRAMP2 Location and Genomic Structure.- NRAMP2 Functions.- NRAMP2 Polymorphisms.- NRAMP2 Polymorphisms and Human Diseases Susceptibility.
4. Pleiotropic Effects of Nramp (Bcg/Lsh/Ity) Gene Expression on Macrophage Functions; Luis F. Barrera and Martin Olivier.
Resistance to Three Pathogens Controlled by One Gene.- Bcg/Lsh/Ity Gene Expression in Macrophage.- Bcg/Lsh/Ity Gene Pleiotropic Effects on Macrophage Functions.- Nramp, a Candidate Gene for Bcg/Lsh/Ity Gene.- Impact of Nramp Gene Expression on Macrophage.- Signaling Activity and Functions Regulation.
5. Role of Nramp Family in Pro-Inflammatory Diseases; Jenefer M. Blackwell, Hui-Rong Jiang and Jacqueline K. White.
Genetic Associations with Pro-Inflammatory Autoimmune Disease in Man.- Evidence for Gene x Environment Interactions?.- Searching for the Functional Polymorphisms in SLC11A1.- Relating Disease Phenotypes to Pleiotropic Effects of SLC11A1.- A Direct Role for Iron in SLC11A1 Regulated Autoimmune.- Disease Phenotypes?.- Mouse Models to Study Slc11a1 Regulation of Pro-Inflammatory Diseases.
6. Role of Nramp2 (DMT1) in Iron Homeostasis; Nancy C. Andrews.
Mammalian Iron Metabolism.- Roles of Nramp2 (DMT1) in Iron Homeostasis.- Nramp2 (DMT1) in Iron Disorders.
7. Molecular Physiology of the H+-coupled Iron Transporter DMT1; Bryan Mackenzie and Matthias A. Hediger.
Molecular Mechanisms of DMT1.- Substrate Profile.- Structure-Function Analysis of DMT1.- The Role of DMT1 in the Biology of Iron Transport.- Multiple Splice Forms Reveal Discrete Expression.- Control Mechanisms.- DMT1 and its Association with Human Disease.
8. Cellular and Tissue Expression of Rat DMT1 / Nramp; Evan H. Morgan.
Gastrointestinal Tract.- Liver.- Erythroid Tissue.- Brain.- Kidney.- Placenta.
9. Tissue Distribution and Subcellular Localization of Nramp Proteins; Francois Canonne-Hergaux and Philippe Gros.
NRAMP1: Discovery of the Nramp1 Gene.- Tissue and Cellular Expression of Mouse and Human Nramp1 mRNA.- Cellular and Subcellular Expression of the Nramp1 Protein in Macrophages and in Neutrophils.- NRAMP2: Nramp2/DMT1 gene, RNA and Protein Isoforms.- Topology Model of Nramp2/DMT1 Protein.- Nramp2/DMT1: Ubiquitous and Cell Specific Expression.- Nramp2/DMT1 in Epithelial Cells.- Nramp2/DMT1 in Peripheral Tissues.- Nramp2/DMT1 Studies: Rich but Controversial Literature.
10. Plant Metal Transporters with Homology to Proteins of the NRAMP Family; Sebastien Thomine and Julian I. Schroeder.
Genomic Analysis of the NRAMP Family in Plant Species.- Functional Characterization of NRAMP Metal Transport.- Properties in Heterologous Expression Systems.- NRAMP Gene Expression Pattern and Regulation in Plants.- Analysis of NRAMP Functions in Plants.- Conclusions and Perspectives for the Analysis of Plant NRAMP Functions.
11. The Role of Yeast Nramp Metal Transporters in Manganese and Iron Homeostasis; Edward Luk, Laran Jensen and Valeria Culotta.
Historical Perspective: Why the Name SMF?.- The Function of S. cerevisiae Smf1p.- Smf2p as a Manganese Transporter.- Smf3p as an Iron Transporter.- Using Yeast as a Model to Study Nramp Metal Transport from Diverse Species.- Post-Translation Regulation of SMFs by Manganese.- Transcriptional Regulation of SMF3 by Fe.
12. Metal-ion Transporters-From Yeast to Human Diseases; Adiel Cohen, Hannah Nelson and Nathan Nelson.
Discovery of the Yeast Smf1p as a Metal-Ion Transporter Revealed that Metal Ions Function Through NRAMP in Resistance and Sensitivity to Bacterial Infection.- A Glimpse into the Mechanism of Metal-Ion Uptake.- Expression of Heterologous Metal-Ion Transporters in Yeast Cells.- The Involvement of NRAMP in Diseases.
13. Regulation of Bacterial MntH Genes; John D. Helmann.
Mycobacterium tuberculosis.- Bacillus subtilis.- Staphylococcus aureus.- Escherichia coli and Salmonella enterica serovar Typhimurium.
14. Manganese and Iron Transport by Prokaryotic Nramp Family Transporters; Krisztina M. Papp, David G. Kehres and Michael E. Maguire.
Nramp Proteins in Prokaryotes.- Physiological Cation Transport.- Transport Mechanism.- Regulation of MntH.- Other Mn2+ Transporters.- Mn2+ in Pathogenesis.
15. Role of the Nramp Orthologue, MntH, in the Virulence of Mycobacterium Tuberculosis; Pilar Domenech and Stewart T. Cole.
M. tuberculosis Is an Intracellular Pathogen.- Murine Nramp1 and the M. tuberculosis Phagosome.- M. tuberculosis MntH Is Constitutively Expressed.- M. tuberculosis MntH Protein As a Cation Transporter.- Role of the M. tuberculosis MntH Protein in Virulence.
16. Molecular Evolutionary Analysis of the Nramp Family; Etienne Richer, Pascal Courville and Mathieu FM Cellier.
Early Gene Duplication in Eukaryotes Gave the Outparologs 'Prototype' and 'Archetype' Nramp.- Characterization of Bacterial Nramp Orthologs: MntH A and B.- Study of MntH Xenologs: MntH Ca, Ca, Ca.- Proposed Evolutionary Pathway of Bacterial Nramp Genes.- Significance and Implications in the Context of Bacterial Infection.- Index.
