For more than 50 years, scientists, clinicians and students have relied on this reference for information on the pharmacokinetics, mechanisms of action and therapeutic application of drugs. This edition provides the latest information on molecular pharmacology as it redefines the definitive database of pharmacologic therapeutics. All the newly approved drugs are included. More importantly, for each drug class, there is an overview of chemical composition, mechanisms of action, indications and contraindications, clinical applications and potential side-effects. As a course text or a daily reference in clinical practice, this book offers a mix of basic science and clinical coverage as it pertains to effective drug therapy.