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Contemporary Drug Synthesis Jie Jack Li

Contemporary Drug Synthesis By Jie Jack Li

Contemporary Drug Synthesis by Jie Jack Li


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Summary

Drug synthesis comprises the heart of the pharmaceutical business today. Both in early development (identifying and optimizing a lead) as well as in process development (scale-up), the ability to develop elegant and economical synthetic routes proves tantamount to the commercial success of a drug.

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Contemporary Drug Synthesis Summary

Contemporary Drug Synthesis by Jie Jack Li

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: * Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others * Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis * Organizes the drugs into fourteen therapeutic areas for clarity and ease of useProcess chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Contemporary Drug Synthesis Reviews

...the authors have made an excellent selection of drugs and the coverage of the synthetic chemistry employed in their production is exemplary... (Chemistry & Industry, 5th September 2005) ...a clear and easy to use reference for anyone working in drug discovery and development. (E-STREAMS, January 2005) ...a very useful book...for...pharmaceutical industry scientists...[and] the larger medicinal and organic chemistry community... (Journal of Medicinal Chemistry, November 18, 2004) ...an outstanding primer on methods for chemical drug synthesis...the test is most useful, well written, and serves as a useful read for those interested in drug synthesis. (American Journal of Therapeutics, September/October 2004) ...highly interesting...keeps to the facts... (www.organische-chemie.ch) '...I warmly recommend this book to synthetic organic chemists both in industry and in academia.' (Organic Process Research and Development Journal, July 2007)

About Jie Jack Li

JIE-JACK LI, PhD, DOUGLAS S. JOHNSON, PhD, DRAGO R. SLISKOVIC, PhD, AND BRUCE D. ROTH, PhD, are all members of Pfizer Global Research and Development, and are among the most prominent scientists working in drug discovery today.

Table of Contents

Preface. Trade Names and Their Corresponding USANs. Acronyms and Abbreviations. Chapter 1. Antithrombotics: Ticlopidine (Ticlid(r)) and Clopidogrel (Plavix(r)). Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex(r)) and Rofecoxib (Vioxx(r)). Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium(r)). Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec(r)) and Gefitinib (Iressa(r)). Chapter 5. Non-sedating Antihistamines. Chapter 6. Cosmeceuticals: Istretinoin (Accutane(r)), Tazarotene (Tazorac(r)), Minoxidil (Rogaine(r)), and Finasteride (Propecia(r)). Chapter 7. Antibacterials: Ciprofloxacin (Cipro(r)) and Linezolid (Zyvox(r)). Chapter 8. Atypical Antupsychotics. Chapter 9. Atovastatin Calcium (Lipitor(r)). Chapter 10. Antidepressants. Chapter 11. Anti-obesity: Orlistat (Xenical(r)). Chapter 12. Triptans for Migrane. Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra(r)), Vardenafil (Levitra(r)), and Tadalafil (Cialis(r)). Chapter 14. Antiasthmatics. Index.

Additional information

CIN0471214809G
9780471214809
0471214809
Contemporary Drug Synthesis by Jie Jack Li
Used - Good
Hardback
John Wiley & Sons Inc
20040713
240
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in good condition, but if you are not entirely satisfied please get in touch with us

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