In this comprehensive guide, Dr. D'Onofrio approaches the topic of how first-responders, such as teachers, coaches, social workers, guidance counselors, and campus health counselors, can and do treat adolescent self-injury. The topics include: a broad conceptual framework of Self-Injurious Behavior in order to increase awareness of the socio-cultural, emotional, psychological, and behavioral expressions of the phenomenon; specific practical guidelines for school counselors and other potential first-line responders for identifying, assessing, and triaging adolescents who self-injure; and, instructions on how to enlist assistance from teachers, administrators, and parents so that all elements of the student's support network function collaboratively are presented.