Die A Littletells the story of Lora King, a schoolteacher, and her brother Bill, a junior investigator with the district attorney's office. Lora's comfortable, suburban life is jarringly disrupted when Bill falls in love and marries a glamorous yet mysterious young woman named Alice Steele, a Hollywood wardrobe assistant.

Lora soon begins to suspect that things aren't all they seem with Alice. Spurred on by inconsistencies in Alice's personal history, Lora finds herself lured into the dark alleys and mean streets of seamy Los Angeles. She uncovers a shadowy world of drugs, prostitution, and ultimately, murder. But the deeper Lora digs to uncover Alice's secrets, the more her own life begins to resemble Alice's sinister past - and present.