Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics.