Preface.- Preclinical effects of antipsychotic drugs.- Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the development of an MDMA (ecstasy) Substance Use Disorder.- The Abuse Potential of Prescription Opioids in Humans - Closing in on the First Century of Research.- Over-the-Counter codeine -from therapeutic use to dependence, and the grey areas in between.- Injection of pharmaceuticals designed for oral use: Harms experienced and effective harm reduction through filtration.- Misuse of Methylphenidate.- Misuse and Associated Harms of Quetiapine, and Other Atypical Antipsychotics.- Benzodiazepines.- Recent trends in alcohol and other drug use among police detainees in New Zealand, 2010-2015.- The Impact of Legalizing and Regulating Weed: Issues with Study Design and Emerging Findings in the U.S.