The authors have aimed to produce a textbook for courses in cellular pathology, both in the United Kingdom and elsewhere. Also, they aimed to produced a book as a practical companion of "Theory and Practice of Histological Techniques" (Bancroft and Stevens, 1990) and to produce a laboratory manual containing a full repertoire of standard and non-standard, well-known and not-so-well-known histological techniques. The authors have tried to appeal to the laboratory scientist and pathologist by anticipating the techniques required in the busy laboratory situation. The book is primarily designed to cover demonstration techniques. For this edition, the authors have incorporated a number of new techniques and, where appropriate, different uses for existing ones. They provide a discussion of the theoretical aspects of the various methods and have given increased prominence to the associated pathology. They have sought to address the needs of the laboratory in terms of new techniques. In particular, immunocytochemistry has an important role and in view of its role in diagnosis, they have supplemented this chapter with the views of a diagnostician.