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Genetic Toxicology By James M. Parry

Genetic Toxicology by James M. Parry

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Summary

Evaluating potential mutagenic activity is a critical step in assessing the safety of both new and pre-existing chemical types. In this book, expert contributors help to satisfy the demand for education in this vitally important field of research.

Genetic Toxicology Summary

Genetic Toxicology: Principles and Methods by James M. Parry

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Table of Contents

1. The Application of Structure Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals

Philip Judson

2. Bacterial Mutagenicity Assays: Test Methods

David Gatehouse

3. The Mouse Lymphoma Assay

Melvyn Lloyd and Darren Kidd

4. Mammalian Cell HPRT Gene Mutation Assay: Test Methods

George E. Johnson

5. The In Vitro Mammalian Chromosome Aberration Test

Gill Clare

6. The Interpretation and Analysis of Cytogenetic Data

Natalie Danford

7. The In Vitro Micronucleus Assay

Ann T. Doherty

8. The In Vitro and In Vivo Comet Assays

Brian Burlinson

9. Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay

Jian Hong Wu and Nigel J. Jones

10. 32P-Postlabelling for the Sensitive Detection of DNA Adducts

Nigel J. Jones

11. Methods for the Detection of DNA Adducts

Karen Brown

12. The GADD45a-GFP GreenScreen HC Assay

Richard M. Walmsley and Matthew Tate

13. Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considerations for Gene Expression Analysis

Shareen H. Doak and Zoulikha M. Zair

14. Cytogenetic In Vivo Assays in Somatic Cells

Ann T. Doherty, Adolph Baumgartner, and Diana Anderson

15. Cytogenetic Methods in Human Biomonitoring: Principles and Uses

Raluca A. Mateuca, Ilsa Decordier, and Micheline Kirsch-Volders

16. The Measurement of Induced Genetic Change in Mammalian Germ Cells

Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo

17. Transgenic Animal Mutation Models: A Review of the Models and How They Function

Steve Dean

18. Analysis of Genotoxicity Data in a Regulatory Context

Ian de G. Mitchell and David O.F. Skibinski

Additional information

NPB9781617794209
9781617794209
1617794201
Genetic Toxicology: Principles and Methods by James M. Parry
New
Hardback
Humana Press Inc.
2011-12-07
433
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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