Part I. Introduction Molecular and Genetic Aspects of Lung Cancer William N. Rom and Kam-Meng Tchou-Wong Part II. Detection of Altered Tumor Markers in Clinical Samples for Diagnosis and Prognosis A. Molecular Methods for Prognostic Detection of Altered Tumor Markers: Clinical Implications Molecular Alterations in Lung Cancer: Impact on Prognosis Takashi Kijima, Gautam Maulik, and Ravi Salgia Cellular Predictive Factors of Drug Resistance in Non-Small Cell Lung Carcinomas Manfred Volm, Reet Koomagi, and Werner Rittgen Clinical Implications of p53 Mutations in Lung Cancer Barbara G. Campling and Wafik S. El-Deiry An Epidemiologic and Clinicopathologic Overview of AIDS-Associated Pulmonary Kaposi's Sarcoma David M. Aboulafia Myeloperoxidase Promoter Region Polymorphism and Lung Cancer Risk Xifeng Wu, Matthew B. Schabath, and Margaret R. Spitz Clinical Utility of Tumor Markers in the Management of Non-Small Cell Lung Cancer Dennis E. Niewoehner and Jeffrey B. Rubins B. Molecular Methods for Prognostic Detection of Altered Lung Tumor Markers in Clinical Samples I. DNA-Based Analysis. Detection of Chromosomal Aberrations in Lung Tissue and Peripheral Blood Lymphocytes Using Interphase Fluorescence In Situ Hybridization (FISH) Randa A. El-Zein and Sherif Z. Abdel-Rahman In Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor Progression W. Nicol Keith A High-Throughput Methodology for Identifying Molecular Targets Overexpressed in Lung Cancers Tongtong Wang and Steven G. Reed Expression Profiling of Lung Cancer Based on Suppression Subtraction Hybridization (SSH) Simone Petersen and Iver Petersen Comparative Genomic Hybridization of Human Lung Cancer Iver Petersen Sensitive Assays for Detection of Lung Cancer: MolecularMarkers in Blood Samples Marcia V. Fournier, Katherine J. Martin, Edgard Graner, and Arthur B. Pardee Fluorescent Microsatellite Analysis in Bronchial Lavage as a Potential Diagnostic Tool for Lung Cancer John K. Field and Triantafillos Liloglou Southern Blotting of Genomic DNA from Lung and Its Tumors: Application to Analysis of Allele Loss on Chromosome 11p15.5 Diana M. Pitterle and Gerold Bepler Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk Xifeng Wu, He Yu, Nimisha Makan, and Margaret R. Spitz II. PCR-Based Analyses. Comparative Multiplex PCR and Allele-Specific Expression Analysis in Human Lung Cancer: Tools to Facilitate Target Identification Jim Heighway, Daniel Betticher, Teresa Knapp, and Paul Hoban Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT Veerle A. M. C. Somers and Frederick B. J. M. Thunnissen Detection of K-ras and p53 Mutations by 'Mutant-Enriched' PCR-RFLP Marcus Schuermann Detection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer Factor Judy M. Coulson, Samreen I. Ahmed, John P. Quinn, and Penella J. Woll III. Immunohistochemical Analyses Utilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung Tumors Nelson G. Ordonez Molecular Biologic Substaining of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffin-Embedded Tissue Mary-Beth Moore Joshi, Thomas A. D'Amico, and David H. Harpole, Jr A Sensitive Immunofluorescence Assay for Detection of p53 Protein in the Sputum Zumei Feng, Defa Tian, and Radoslav Goldman SPR1: An Early Molecular Marker for Bronchial Carcinogenesis Derick Lau, Linlang Guo, Andrew
