New York is known as the city that never sleeps. On its constantly hustling, bustling streets crime never sleeps either; and nor do the ever-vigilant crime-fighters who strive to solve its murder cases and bring perpetrators to justice using the very latest in forensic investigative techniques. Now, high-tech science comes to the Big Apple as Detective Mack Taylor (Sinise) and his partner, Detective Stella Bonasera (Kanakaredes), lead a team of dedicated, case-cracking experts in the gritty, kinetic city.