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A Genetic Switch Mark Ptashne

A Genetic Switch von Mark Ptashne

A Genetic Switch Mark Ptashne


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Zusammenfassung

Concerned with how lambda, a virus, uses its DNA to direct its growth, this book looks at the mechanisms which control the turning on and off of genes during development of lambda. Ptashne considers gene regulation in higher organisms.

A Genetic Switch Zusammenfassung

A Genetic Switch: Gene Control and Phage Lambda Mark Ptashne

A Genetic Switch is concerned with how a virus called lambda uses its genes - its DNA - to direct its growth. Biologists have long wished to know how genes are 'switched' on and off during development and, aberrantly, in diseased states.

Inhaltsverzeichnis

1. The Master Elements of Control:Components of the SwitchThe Action of Repressor and CroInduction - Flipping the SwitchCooperativity - Switch Stability and SensitivityThe Effect of AutoregulationOther Cases2. Protein-DNA Interactions and Gene Control:The OperatorRepressorCroAmino Acid-Base Pair InteractionsThe PromoterGene Control3. Control Circuits - Setting the Switch:A Brief Overview of Lambda GrowthControl of TranscriptionThe DecisionControl of Integration and ExcisionOther PhagesThe SOS ResponsePathways and Cell Development4. How do we Know - The Key Experiments:The Repressor IdeaThe Repressor Problem in the Early 1960sRepressor Isolation and DNA-BindingMaking More RepressorThe Claims of Chapters One and Two5. Eukaryotic Gene Regulation - An Overview:IntroductionEukaryotic Genes and their PolymerasesActivationRepressionCooperativityRegulators Assembled for Non-identical ComponentsSpeculations on Development and EvolutionCaveats6. Eukaryotic Gene Regulation - Experiments and Examples:BackgroundTwo Functions of an Activator: DNA Binding and ActivationDNA Binding StructuresActivating RegionsAction at a Distance- LoopingActivation In Vivo and In VitroSquelchingRepressionRegulators Assembled from Non-identical ComponentsMore CooperativityThe Case of EveConclusion; Appendix OneDesigning an Efficient DNA-binding ProteinAppendix TwoStrong and Weak InteractionsAppendix ThreeControl of Transcription in Eukaryotes and Prokaryotes - a common mechanism

Zusätzliche Informationen

GOR001946701
9780865422094
0865422095
A Genetic Switch: Gene Control and Phage Lambda Mark Ptashne
Gebraucht - Sehr Gut
Broschiert
John Wiley and Sons Ltd
19920700
270
N/A
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