There are good friends. Then there are best friends. Cate Wishart and Margie Holland shared some traumatic teenage years and left school promising to be best friends forever. But two decades later they've drifted to opposite ends of the country and communicate only through Christmas cards. Cate's married to a doctor desired by every woman that meets him and mother to three lively girls. But she's drowning in domesticity, starved of her husband's affection, and yearning for a life of her own. Margie's a senior news producer who deals deftly with everything that live TV can throw at her, yet can't control her drinking or her tele-shopping compulsion. Unmarried, her affair with the network's star correspondent (who has a girl in every war zone) is going nowhere! Until a class reunion brings Cate and Margie back together, reminding them how much fun a best friend can be and sending their lives in surprising new directions!