List of contributors, v Preface, ix List of abbreviations, xi Part 1 Understanding evidence and pain, 1 1 Why evidence matters, 3 Andrew Moore and Sheena Derry 2 Clinical trial design for chronic pain treatments, 14 Alec B. O Connor and Robert H. Dworkin 3 Introduction to evaluation of evidence, 31 Eija Kalso 4 Neurobiology of pain, 42 Victoria Harvey and Anthony Dickenson 5 Intractable pain and the perception of time: every patient isan anecdote, 52 David B. Morris 6 Psychology of chronic pain and evidence-based psychologicalinterventions, 59 Christopher Eccleston Part 2 Clinical pain syndromes: the evidence, 69 7 Chronic low back pain, 71 Maurits van Tulder and Bart Koes 8 Chronic neck pain and whiplash, 83 Allan Binder 22 Headache, 279 Peer Tfelt-Hansen 23 Chest pain syndromes, 292 Austin Leach and Michael Chester Part 3 Cancer pain, 309 24 Oncologic therapy in cancer pain, 311 Rita Janes and Tiina Saarto 25 Cancer pain: analgesics and co-analgesics, 327 Rae Frances Bell 26 Psychologic interventions for cancer pain, 337 Francis J. Keefe, Tamara J. Somers and Amy Abernethy 27 Transcutaneous electrical nerve stimulation and acupuncture,348 Mark I. Johnson Part 4 Treatment modalities: the evidence, 367 28 Interventional therapies, 369 Anthony Dragovich and Steven P. Cohen 29 Spinal cord stimulation for refractory angina, 400 Mats Borjesson, Clas Mannheimer, Paulin Andrell andBengt Linderoth 30 Rehabilitative treatment for chronic pain, 407 James P. Robinson, Raphael Leo, Joseph Wallach, Ellen McGoughand Michael Schatman 31 Drug treatment of chronic pain, 424 Henry McQuay 32 Complementary therapies for pain relief, 434 Edzard Ernst Index, 439